1ST-TRIMESTER MATERNAL SERUM ALPHA-FETOPROTEIN AND CHORIONIC-GONADOTROPIN IN ANEUPLOID PREGNANCIES

被引：32

作者：

JOHNSON, A ^{[1
]}

COWCHOCK, FS ^{[1
]}

DARBY, M ^{[1
]}

WAPNER, R ^{[1
]}

JACKSON, LG ^{[1
]}

机构：

[1] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DIV MED GENET,PHILADELPHIA,PA 19107

来源：

PRENATAL DIAGNOSIS | 1991年 / 11卷 / 07期

关键词：

ALPHA-FETOPROTEIN; CHORIONIC GONADOTROPIN; CHROMOSOME ABNORMALITIES; PRENATAL DIAGNOSIS;

D O I：

10.1002/pd.1970110706

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

First-trimester maternal serum alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) levels were measured in samples from 29 women with cytogenetically abnormal pregnancies and 145 women with cytogenetically normal pregnancies matched for gestational age, race, and sample storage time. All patients had a risk of fetal aneuploidy greater than or equal to that of a mother 35 years of age. AFP was significantly lower in samples from pregnancies affected with trisomy 21 (0.67 MoM; p < 0.05), while HCG values were no different from those of matched controls. Trisomies 13 and 18 could not be distinguished from matched controls by AFP. However, levels of HCG were significantly lower in such pregnancy samples, with median values of 0.65 MoM in trisomy 13 and 0.32 MoM in trisomy 18 (p < 0.05). Variations in AFP and HCG levels suggest that expressed differences between autosomal aneuploidies include differences in fetal and placental protein production in the first trimester.

引用

页码：443 / 450

页数：8

共 16 条

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