5-HYDROXYINDOLE SLOWS DESENSITIZATION OF THE 5-HT3 RECEPTOR-MEDIATED ION CURRENT IN N1E-115 NEUROBLASTOMA-CELLS

被引：37

作者：

KOOYMAN, AR ^{[1
]}

VANHOOFT, JA ^{[1
]}

VIJVERBERG, HPM ^{[1
]}

机构：

[1] UNIV UTRECHT,TOXICOL RES INST,POB 80176,3508 TD UTRECHT,NETHERLANDS

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1993年 / 108卷 / 02期

关键词：

5-HYDROXYTRYPTAMINE; 5-HT3; RECEPTOR; DESENSITIZATION; 5-HYDROXYINDOLE; N1E-115 MOUSE NEUROBLASTOMA; WHOLE-CELL VOLTAGE CLAMP;

D O I：

10.1111/j.1476-5381.1993.tb12795.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Effects of 5-hydroxyindole (5-OHi) on 5-HT3 receptor-operated ion current were investigated in voltage-clamped N1E-115 neuroblastoma cells. In the presence of 1 mm 5-OHi, the amplitudes of inward currents induced by the agonists 5-hydroxytryptamine (5-HT), 2-methyl-5-HT and dopamine were enhanced and desensitization of the responses was markedly slowed down. The results indicate that 5-OHi selectively modifies the desensitization of the 5-HT3 receptor-mediated ion current.

引用

页码：287 / 289

页数：3

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