EFFECTS OF ADMINISTRATION OF MURINE RECOMBINANT IL-4 ON THE RESISTANCE OF MICE TO LISTERIA-MONOCYTOGENES INFECTION

被引：7

作者：

IIZAWA, Y ^{[1
]}

CZUPRYNSKI, C ^{[1
]}

机构：

[1] UNIV WISCONSIN,SCH VET MED,DEPT PATHOBIOL SCI,2015 LINDEN DR W,MADISON,WI 53706

来源：

IMMUNOLOGY LETTERS | 1992年 / 32卷 / 02期

关键词：

INTERLEUKIN-4; MOUSE; LISTERIA-MONOCYTOGENES; RESISTANCE;

D O I：

10.1016/0165-2478(92)90113-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice given recombinant murine interleukin-4 as a single i.v. bolus concomitant with a Listeria monocytogenes challenge did not display increased anti-listeria resistance. Under certain conditions, IL-4 administration slightly increased the bacterial burdens in the spleens and livers of infected mice. This finding is consistent with previous reports that endogenous IL-4, or transfer of IL-4 producing TH2 cells, can be detrimental to host defense against microbial infection.

引用

页码：185 / 190

页数：6

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