THE ANALGESIA INDUCED BY INTRATHECAL INJECTION OF RUTHENIUM RED

被引：10

作者：

OHKUBO, T

SHIBATA, M

TAKAHASHI, H

机构：

[1] Department of Pharmacology, Fukuoka Dental College, Sawara-ku, Fukuoka, 814-01

来源：

PAIN | 1993年 / 54卷 / 02期

关键词：

RUTHENIUM RED; SUBSTANCE-P; CAPSAICIN; ANALGESIA;

D O I：

10.1016/0304-3959(93)90212-8

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Intrathecally (i.t.) administered ruthenium red (40, 80, 160 ng) dose-dependently inhibited formalin-induced nociceptive response. Ruthenium red caused a significant inhibition of pain-related behavioral responses induced by i.t. capsaicin but not by i.t. substance P. These results suggest that ruthenium red produces analgesia by inhibiting the release of neuropeptides in the spinal cord.

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收藏

页码：219 / 221

页数：3

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