PROSPECTIVE EVALUATION OF TOPICAL ANTIBIOTICS FOR PREVENTING INFECTIONS IN UNCOMPLICATED SOFT-TISSUE WOUNDS REPAIRED IN THE ED

Objective: To determine differences in infection rates among uncomplicated, repaired wounds managed with: topical bacitracin zinc (BAC); neomycin sulfate, bacitracin zinc. and polymyxin B sulfate combination (NEO): silver sulfadiazine (SIL); and petrolatum (PTR). Methods: This was a prospective. randomized, double-blind, placebo-controlled study conducted at a military community hospital with an emergency medicine residency program. Patients were enrolled if they: presented to the ED within 12 hours of injury and did not have puncture wounds, allergies to the agents used, or a history of immunocompromise: were not receiving antibiotics. chemotherapy, or steroids at the time of presentation; had not taken antibiotics within the preceding seven days. did not have an underlying fracture, and were not pregnant as determined by history. Local anesthetics without epinephrine and high-pressure irrigation with normal saline were used for all the patients. Wound scrubbing, debridement, and polyglactin subcutaneous (SQ) suture placement were carried out when necessary. Interrupted simple sutures using a monofilament, nonabsorbable material were used for skin closure. Numbered, randomized vials were given to all patients, with standardized instructions to inspect, clean, and redress their wounds three times a day. The wounds were evaluated for clinical infection at the time of follow-up. Results: Among the groups, there was no difference in patient ages; gender: wound location, type, length, or depth: time elapsed from injury to ED treatment: number of wounds scrubbed or necessitating debridement; number of SQ and cutaneous sutures used; and rate of compliance with returning the used vial of dispensed topical agent. The wound infection rates for the treatment groups were: BAC. six of 109 (5.5%). NEO, five of 110 (4.5%); SIL, 12 of 99 (12.1%); and PTR, 19 of 108 (17.6%) (p = 0.0034). Conclusion: The use of topical antibiotics resulted in significantly lower infection rates than did the use of a petrolatum control. BAC and NEO had the lowest wound infection rates.