OPEN ACCESS ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION MASS-SPECTROMETRY FOR ROUTINE SAMPLE ANALYSIS

被引：38

作者：

TAYLOR, LCE ^{[1
]}

JOHNSON, RL ^{[1
]}

RASO, R ^{[1
]}

机构：

[1] BIOTECH MS,FISONS INSTRUMENTS ORGAN ANAL,ALTRINCHAM WA14 5RZ,ENGLAND

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 1995年 / 6卷 / 05期

关键词：

D O I：

10.1016/1044-0305(94)00124-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the introduction and use of an atmospheric pressure chemical ionization liquid chromatography-mass spectrometry instrument that has been designed specifically for use by the synthetic chemist on an open access, walk-in basis. This instrument has been configured with an easy-to-use sample log-in terminal that requires the user to provide only a sample identification number and a user name. Sample analysis takes approximately 4 min and provides the synthetic and medicinal chemist with rapid and reliable mass spectrometry analysis. Since installation of the system, it has analyzed an average of about 80 samples per day and has the capacity to run over 100 samples per day without the intervention of a specialist operator. This capability has eliminated the need for an operator to analyze routine samples and allows the mass spectroscopist more time to deal with problem solving.

引用

页码：387 / 393

页数：7

共 16 条

[1]

BEAN M, 1993, 41ST P ANN C MASS SP, pA1104

[2]

DEJOHN DE, 1994, 42ND P ANN C MASS SP, P157

[3] QUANTITATIVE-ANALYSIS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ATMOSPHERIC-PRESSURE CHEMICAL IONIZATION MASS-SPECTROMETRY - THE DETERMINATION OF THE RENIN INHIBITOR CP-80,794 IN HUMAN SERUM [J].

FOUDA, H ;

NOCERINI, M ;

SCHNEIDER, R ;

GEDUTIS, C .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1991, 2 (02) :164-167

[4] DETERMINATION OF L-654,066, A NEW 5-ALPHA-REDUCTASE INHIBITOR IN PLASMA BY LIQUID-CHROMATOGRAPHY ATMOSPHERIC-PRESSURE CHEMICAL IONIZATION MASS-SPECTROMETRY [J].

GILBERT, JD ;

OLAH, TV ;

BARRISH, A ;

GREBER, TF .

BIOLOGICAL MASS SPECTROMETRY, 1992, 21 (07) :341-346

[5] DETERMINATION OF L-365,260, A NEW CHOLECYSTOKININ RECEPTOR (CCK-B) ANTAGONIST, IN PLASMA BY LIQUID-CHROMATOGRAPHY ATMOSPHERIC-PRESSURE CHEMICAL IONIZATION MASS-SPECTROMETRY [J].

GILBERT, JD ;

HAND, EL ;

YUAN, AS ;

OLAH, TV ;

COVEY, TR .

BIOLOGICAL MASS SPECTROMETRY, 1992, 21 (02) :63-68

[6]

GIORDANI AB, 1990, 38TH P ANN C MASS SP, P976

[7] FLOW-INJECTION THERMOSPRAY(R) MASS-SPECTROMETRY FOR THE AUTOMATED-ANALYSIS OF POTENTIAL AGRICULTURAL CHEMICALS [J].

HAYWARD, MJ ;

SNODGRASS, JT ;

THOMSON, ML .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1993, 7 (01) :85-91

[8] AUTOMATIC SAMPLE LOADER FOR LKB MODEL-9000 MASS-SPECTROMETER [J].

KATH, GS ;

MCKEEL, WJ ;

SMITH, JL ;

LIESCH, JM .

REVIEW OF SCIENTIFIC INSTRUMENTS, 1986, 57 (12) :3114-3119

[9] THE SENSITIVE DETERMINATION OF ABANOQUIL IN BLOOD BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ATMOSPHERIC-PRESSURE IONIZATION MASS-SPECTROMETRY [J].

KAYE, B ;

CLARK, MWH ;

CUSSANS, NJ ;

MACRAE, PV ;

STOPHER, DA .

BIOLOGICAL MASS SPECTROMETRY, 1992, 21 (11) :585-589

[10]

KIPLINGER J, 1993, 41ST P ANN C MASS SP, pB1104

← 1 2 →