MALE-MEDIATED BEHAVIORAL ABNORMALITIES

被引：11

作者：

LOWERY, MC

AU, WW

ADAMS, PM

WHORTON, EB

LEGATOR, MS

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT PREVENT MED & COMMUNITY HLTH,GALVESTON,TX 77550

[2] UNIV TEXAS,HLTH SCI CTR,DALLAS,TX 75235

来源：

MUTATION RESEARCH | 1990年 / 229卷 / 02期

关键词：

Behaviortal abnormalities; Developmental deficits; Ionizing radiation; Male-mediated effects;

D O I：

10.1016/0027-5107(90)90095-L

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The assessment of behaviral development in the progeny of males exposed to known mutagenic chemicals is a potentially sensitive endpoint for detecting transmissible abonormalities. A genetic components is demonstrated as these behavioral abnormalities can also be passed on to the F2 generation. In this review, experimental studies exploring transmission of behavioral deficits from paternal exposure to drugs, chemicals and radiation are addressed. Additionally included is a brief synopis of recent work perfomed in our laboratory investigating such abnormalities in offspring from male rats exposed to ionizing radiations. The implications of these behavioral endpoints to humans is also discussed. © 1990.

引用

页码：213 / 229

页数：17

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