N-METHYL-BENZYLAMINE, A METABOLITE OF PARGYLINE IN MAN

被引：17

作者：

PIRISINO, R ^{[1
]}

CIOTTOLI, GB ^{[1
]}

BUFFONI, F ^{[1
]}

ANSELMI, B ^{[1
]}

CURRADI, C ^{[1
]}

机构：

[1] FLORENCE UNIV,DEPT CLIN PHARMACOL,FLORENCE,ITALY

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1979年 / 7卷 / 06期

关键词：

D O I：

10.1111/j.1365-2125.1979.tb04648.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. N‐methyl‐benzylamine was identified in human urine and plasma after the administration of pargyline in man. This metabolite was identified by thin layer chromatography mobility, gas chromatographic retention time and mass spectrum relative to authentic N‐methyl‐benzylamine. 2. [14C]‐N‐methyl‐benzylamine, together with a small amount of [14C]‐ benzylamine, was formed in vitro from [14C]‐pargyline when this was incubated with human and rat liver microsomes. 3. The urinary excretion rates of pargyline and its metabolite have also been described. 1979 The British Pharmacological Society

引用

页码：595 / 598

页数：4

共 5 条

[1] ROUTINE DETECTION AND IDENTIFICATION IN URINE OF STIMULANTS AND OTHER DRUGS SOME OF WHICH MAY BE USED TO MODIFY PERFORMANCE IN SPORT [J].