OVARIAN STIMULATION IN PREVIOUS FAILURES FROM INVITRO FERTILIZATION - DISTINCTION OF 2 GROUPS OF POOR RESPONDERS

被引：23

作者：

TANBO, T

ABYHOLM, T

BJORO, T

DALE, PO

机构：

[1] Department of Obstetrics and Gynaecology, National Hospital, University of Oslo, Oslo

[2] Department of Clinical Chemistry, National Hospital, University of Oslo, Oslo

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 07期

关键词：

FSH; IVF; Ovarian failure;

D O I：

10.1093/oxfordjournals.humrep.a137188

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Forty-three patients who responded poorly to previous stimulation with clomiphene citrate (CC)/human menopausal gonadotrophin (HMG) for IVF were followed during 70 further cycles. Eighteen patients had a normal FSH response to CC in the previous cycle, while 25 had an abnormal FSH response. Three stimulation protocols were used: buserelin/ HMG, CC/HMG and HMG only. No difference between the two groups was observed in the dose of HMG used for any stimulation protocol. More cycles were cancelled due to a poor response in the abnormal response group compared to the normal response group. In the completed cycles, the maximum oestradiol level and number of oocytes retrieved were lower in the abnormal response group compared to the normal response group. The total pregnancy rate per patient, including spontaneous conceptions during the study period, was lower in the abnormal response group compared to the normal response group, 4 versus 33%. We conclude that poor responders with an abnormal FSH response to CC have a latent ovarian failure with a low chance of success in further IVF attempts. © 1990 Oxford University Press.

引用

页码：811 / 815

页数：5

共 17 条

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