A-HOMOPOLYMERIC AND T-HOMOPOLYMERIC STRETCHES MEDIATE A DNA INVERSION IN PLASMODIUM-FALCIPARUM WHICH RESULTS IN LOSS OF GENE-EXPRESSION

被引：30

作者：

POLOGE, LG ^{[1
]}

DEBRUIN, D ^{[1
]}

RAVETCH, JV ^{[1
]}

机构：

[1] SLOAN KETTERING MEM CANC CTR,1275 YORK AVE,RYE,NY 10580

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 06期

关键词：

D O I：

10.1128/MCB.10.6.3243

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ring-infected erythrocyte surface antigen-negative isolates of Plasmodium falciparum demonstrate a complex DNA rearrangement with inversion of 5' coding sequences, deletion of upstream and flanking sequences, and healing of the truncated chromosome by telomere addition. An inversion intermediate that results in the telomeric gene structure for RESA has been identified in the pathway. This inversion creates a mitotically stable substrate for the sequence-specific addition of telomere repeats at the deletion breakpoint.

引用

页码：3243 / 3246

页数：4

共 16 条

[1] CHARACTERIZATION OF AN S-ANTIGEN SYNTHESIZED BY SEVERAL ISOLATES OF PLASMODIUM-FALCIPARUM [J].

ANDERS, RF ;

BROWN, GV ;

EDWARDS, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (21) :6652-6656

[2] LOCALIZATION OF THE RING-INFECTED ERYTHROCYTE SURFACE-ANTIGEN (RESA) OF PLASMODIUM-FALCIPARUM IN MEROZOITES AND RING-INFECTED ERYTHROCYTES [J].

BROWN, GV ;

CULVENOR, JG ;

CREWTHER, PE ;

BIANCO, AE ;

COPPEL, RL ;

SAINT, RB ;

STAHL, HD ;

KEMP, DJ ;

ANDERS, RF .

JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 162 (02) :774-779

[3] EXPRESSION OF THE RESA GENE IN PLASMODIUM-FALCIPARUM ISOLATE FCR3 IS PREVENTED BY A SUBTELOMERIC DELETION [J].

CAPPAI, R ;

VANSCHRAVENDIJK, MR ;

ANDERS, RF ;

PETERSON, MG ;

THOMAS, LM ;

COWMAN, AF ;

KEMP, DJ .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (08) :3584-3587

[4] CHROMOSOME SIZE POLYMORPHISMS IN PLASMODIUM-FALCIPARUM CAN INVOLVE DELETIONS AND ARE FREQUENT IN NATURAL PARASITE POPULATIONS [J].

CORCORAN, LM ;

FORSYTH, KP ;

BIANCO, AE ;

BROWN, GV ;

KEMP, DJ .

CELL, 1986, 44 (01) :87-95

[5] STRUCTURE OF THE RESA GENE OF PLASMODIUM-FALCIPARUM [J].

FAVALORO, JM ;

COPPEL, RL ;

CORCORAN, LM ;

FOOTE, SJ ;

BROWN, GV ;

ANDERS, RF ;

KEMP, DJ .

NUCLEIC ACIDS RESEARCH, 1986, 14 (21) :8265-8277

[6] G INVERSION IN BACTERIOPHAGE-MU - A NOVEL WAY OF GENE-SPLICING [J].

GIPHARTGASSLER, M ;

PLASTERK, RHA ;

VANDEPUTTE, P .

NATURE, 1982, 297 (5864) :339-342

[7] PLASMODIUM-FALCIPARUM IN CULTURE - ESTABLISHMENT OF ADDITIONAL STRAINS [J].

JENSEN, JB ;

TRAGER, W .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1978, 27 (04) :743-746

[8]

KEMP DJ, 1983, P NATL ACAD SCI-BIOL, V80, P3787, DOI 10.1073/pnas.80.12.3787

[9] MOLECULAR KARYOTYPE OF PLASMODIUM-FALCIPARUM - CONSERVED LINKAGE GROUPS AND EXPENDABLE HISTIDINE-RICH PROTEIN GENES [J].

KEMP, DJ ;

THOMPSON, JK ;

WALLIKER, D ;

CORCORAN, LM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) :7672-7676

[10] A CHROMOSOMAL REARRANGEMENT IN A PLASMODIUM-FALCIPARUM HISTIDINE-RICH PROTEIN GENE IS ASSOCIATED WITH THE KNOBLESS PHENOTYPE [J].

POLOGE, LG ;

RAVETCH, JV .

NATURE, 1986, 322 (6078) :474-477

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