PERTUSSIS TOXIN INHIBITS ENDOTHELIUM-DEPENDENT RELAXATIONS EVOKED BY FLUORIDE

被引：30

作者：

FLAVAHAN, NA ^{[1
]}

VANHOUTTE, PM ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,DEPT PHYSIOL & BIOPHYS,ROCHESTER,MN 55905

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 178卷 / 01期

关键词：

Bacterial toxins; EDRF; Endothelium-derived relaxing factor; G-proteins; guanine nucleotide regulatory proteins;

D O I：

10.1016/0014-2999(90)94803-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Fluoride is a direct activator of G-proteins. In isolated rings of canine coronary artery, fluoride caused relaxation of rings with endothelium, but only slight contraction of rings denuded of endothelium. The endothelium-dependent relaxations to fluoride were inhibited by pertussis toxin, an inhibitor of G-proteins, or by methylene blue, an inhibitor of soluble guanylate cyclase. Therefore, fluoride causes endothelium-dependent relaxations in part by activating a pertussis toxin-sensitive G-protein in the endothelial cells. © 1990.

引用

页码：121 / 124

页数：4

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