N-SUBSTITUTION OF 2-METHYL-4(5)-NITRO-1H-IMIDAZOLE - A NEW, HIGH-YIELDING METHOD FOR PREPARATION OF 4-NITRO ISOMERS

被引：21

作者：

RAO, AKSB ^{[1
]}

RAO, CG ^{[1
]}

SINGH, BB ^{[1
]}

机构：

[1] RECKITT & COLMAN INDIA LTD,CTR RES & DEV,PLOT 176,SIPCOT IND COMPLEX,HOSUR 635126,TAMIL NADU,INDIA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 11期

关键词：

D O I：

10.1021/jo00298a070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Substituted products from 2-methyl-4(5)-nitro-lH-imidazole (1) are of great utility as chemotherapeutic agents. Tinidazole and metronidazole, belonging to the 5-nitro series, have been widely used in the treatment of protozoal infections like trichomoniasis.1,2The 4-nitro compounds are gaining pharmacological significance as immunosuppressants,3 aldehyde dehydrogenase inhibitors,4 potential radio sensitizers,5 and radiotherapy synergists6. © 1990, American Chemical Society. All rights reserved.

引用

页码：3702 / 3704

页数：3

共 20 条

[1]

BOYER JH, 1986, NITROAZOLES C NITROD, P79

[2] NITROIMIDAZOLE DERIVATIVES . RELATIONSHIP BETWEEN STRUCTURE AND ANTITRICHOMONAL ACTIVITY [J].