CLINICAL EFFECTS AND CERVICAL TISSUE CHANGES AFTER TREATMENT WITH 16, 16-DIMETHYL-TRANS-DELTA-2 PGE1 METHYLESTER IN THE 1ST TRIMESTER

被引：10

作者：

DING, JQ ^{[1
]}

GRANBERG, S ^{[1
]}

NORSTROM, A ^{[1
]}

机构：

[1] SHANGHAI MED UNIV 2,PEOPLES HOSP 9,DEPT OBSTET & GYNECOL,SHANGHAI,PEOPLES R CHINA

来源：

PROSTAGLANDINS | 1990年 / 39卷 / 03期

关键词：

D O I：

10.1016/0090-6980(90)90047-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cervagem pessaries, containing 1 mg of 16, 16-dimethyl-trans Δ 2-PGE1 methylester, was administered in the posterior vaginal fornix 4 h before vacuum aspiration in the 1st trimester. The effects of cervical dilatation, cervical collagen metabolism and cervical smooth muscle activity were investigated. In treated women the mean cervical dilatation was 7.9 mm as compared with 3.9 mm in controls. The in vitro incorporation of 14C proline in cervical tissue as well as the hydrolytic activity against a synthetic "collagen-like" polypeptide was increased after treatment with cervagem. The cervical smooth muscle sensitivity to prostaglandins, as revealed by inhibition of muscle activity, was higher in treated women than in controls. It is concluded that cervical dilatation, as induced by cervagem, involves an adaptation of both connective tissue and smooth muscle components. © 1990.

引用

页码：281 / 285

页数：5

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