HIGHLY DIASTEREOSELECTIVE INTERESTERIFICATION REACTIONS INVOLVING A RACEMIC ACETATE AND A RACEMIC CARBOXYLIC-ACID CATALYZED BY LIPASE ENZYMES

被引：17

作者：

FOWLER, PW

MACFARLANE, ELA

ROBERTS, SM

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 07期

关键词：

D O I：

10.1039/c39910000453

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of the acetate (+/-)-8 with the acid (+/-)-2 using Candida cylindracea lipase or Lipase AY as catalyst gave mainly the (R,R)-diastereoisomer 4 (91 +/- 0.5%) with minimal amounts of the other diastereoisomers 3,5 and 6 (< 5.5%).

引用

页码：453 / 455

页数：3

共 8 条

[1] PREPARATIVE PRODUCTION OF OPTICALLY-ACTIVE ESTERS AND ALCOHOLS USING ESTERASE-CATALYZED STEREOSPECIFIC TRANS-ESTERIFICATION IN ORGANIC MEDIA [J].

CAMBOU, B ;

KLIBANOV, AM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (09) :2687-2692

[2] RESOLUTION OF RACEMIC MIXTURES VIA LIPASE CATALYSIS IN ORGANIC-SOLVENTS [J].

KIRCHNER, G ;

SCOLLAR, MP ;

KLIBANOV, AM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (24) :7072-7076

[3] ENZYME-CATALYZED INTERESTERIFICATION PROCEDURE FOR THE PREPARATION OF ESTERS OF A CHIRAL SECONDARY ALCOHOL IN HIGH ENANTIOMERIC PURITY [J].

MACFARLANE, ELA ;

ROBERTS, SM ;

TURNER, NJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (07) :569-571

[4]

MACFARLANE ELA, 1991, IN PRESS BIOCATALYSI

[5] KINETIC RESOLUTIONS OF ALIPHATIC-ALCOHOLS WITH A FUNGAL LIPASE FROM MUCOR-MIEHEI [J].

SONNET, PE .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (15) :3477-3479

[6] RECENT ADVANCES IN THE USE OF ENZYME-CATALYZED REACTIONS IN ORGANIC-SYNTHESIS [J].

TURNER, NJ .

NATURAL PRODUCT REPORTS, 1989, 6 (06) :625-644

[7] ENZYMES AS CATALYSTS IN SYNTHETIC ORGANIC-CHEMISTRY [J].

WHITESIDES, GM ;

WONG, CH .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1985, 24 (08) :617-638

[8] DIASTEREO-SELECTIVE AS WELL AS ENANTIO-SELECTIVE LIPASE-CATALYZED ASYMMETRIC HYDROLYSIS OF CHLOROFLUOROMETHYLATED ALCOHOLS [J].

YAMAZAKI, T ;

ICHIKAWA, S ;

KITAZUME, T .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (04) :253-255

← 1 →