MAGNETIC MICROSPHERES - SYNTHESIS OF A NOVEL PARENTERAL DRUG CARRIER

被引：159

作者：

WIDDER, K

FLOURET, G

SENYEI, A

机构：

[1] NORTHWESTERN UNIV,SCH MED,DEPT PHYSIOL,CHICAGO,IL 60611

[2] NORTHWESTERN UNIV,SCH MED,CTR CANC,CHICAGO,IL 60611

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 01期

关键词：

Carriers; drug—magnetic microspheres synthesized; effect of stabilization and heat on drug release in vitro; Delivery; drug—magnetic microspheres synthesized as drug carriers; Microspheres; magnetic—synthesized as drug carriers;

D O I：

10.1002/jps.2600680124

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and characterization of a novel parenteral drug carrier capable of area specific localization by magnetic means are described. The carrier consists of human serum albumin microspheres, average of 1 μm in diameter, in which a magnetizable material (magnetite) and a prototype drug (doxorubicin) are entrapped. Stabilization of the microsphere matrix by formaldehyde, 2,3‐butanedione, and heat conferred equal stability to the matrix but differentially affected the in vitro drug release rate. Released doxorubicin was chemically identical to the starting material. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：79 / 82

页数：4

共 20 条

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DIMARCO A, 1975, CANCER CHEMOTH REP 3, V6, P91

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