EFFECTS OF INTRAAXONAL INJECTION OF CA2+ BUFFERS ON EVOKED RELEASE AND ON FACILITATION IN THE CRAYFISH NEUROMUSCULAR-JUNCTION

被引：47

作者：

HOCHNER, B ^{[1
]}

PARNAS, H ^{[1
]}

PARNAS, I ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,OTTO LOEWI CTR CELLULAR & MOLEC NEUROBIOL,IL-91904 JERUSALEM,ISRAEL

来源：

NEUROSCIENCE LETTERS | 1991年 / 125卷 / 02期

关键词：

CA2+ BUFFER; NEUROMUSCULAR JUNCTION; TRANSMITTER RELEASE; SYNAPSE; FACILITATION;

D O I：

10.1016/0304-3940(91)90032-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ca2+ buffers were injected into the excitatory axon of the crayfish opener muscle. The magnitude and time course of evoked release and of facilitation were measured. EGTA (on-rate about 10(6) M-1s-1) had no effect on evoked release but reduced facilitation. BAPTA and nitr-5, buffers with similar K(d)'s but faster on-rates, reduced both evoked release and facilitation. However, these buffers had no effect on the time course of evoked release. These results show that fast Ca2+ buffers reduce the Ca2 transient associated with evoked release and also the level of residual Ca2+ involved in facilitation. However, Ca2+ buffering is not the mechanism which controls the time course of release.

引用

页码：215 / 218

页数：4

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