EXTRATHYMIC T-CELL SELECTION

被引：17

作者：

ARNOLD, B

SCHONRICH, G

HAMMERLING, GJ

机构：

[1] Institut für Immunologie, Genetik Deutsches Krebsforschungszentrum, Heidelberg

来源：

CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 02期

关键词：

D O I：

10.1016/0952-7915(92)90007-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The T-cell repertoire is formed during T lymphocyte maturation in the thymus. There is, however, increasing evidence that there are additions to, and modifications of, this repertoire by extrathymic events. Most importantly, mature peripheral T cells are not only susceptible to activation signals but also to tolerance induction upon encounter of extrathymic antigen. An understanding of these inactivation processes should result in strategies for specific immunosuppression in organ transplantation and autoimmune diseases.

引用

页码：166 / 170

页数：5

共 30 条

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