HIGH-AFFINITY NERVE GROWTH-FACTOR RECEPTOR (TRK) IMMUNOREACTIVITY IS LOCALIZED IN CHOLINERGIC NEURONS OF THE BASAL FOREBRAIN AND STRIATUM IN THE ADULT-RAT BRAIN

被引：135

作者：

STEININGER, TL

WAINER, BH

KLEIN, R

BARBACID, M

PALFREY, HC

机构：

[1] UNIV CHICAGO, DEPT PHARMACOL & PHYSIOL SCI, 947 E 58TH ST, BOX MC0926, CHICAGO, IL 60637 USA

[2] UNIV CHICAGO, COMM NEUROBIOL, CHICAGO, IL 60637 USA

[3] BRISTOL MYERS SQUIBB, PHARMACEUT RES INST, DEPT MOLEC BIOL, PRINCETON, NJ 08543 USA

来源：

BRAIN RESEARCH | 1993年 / 612卷 / 1-2期

关键词：

LOW-AFFINITY NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN; CHOLINE ACETYLTRANSFERASE; IMMUNOHISTOCHEMISTRY;

D O I：

10.1016/0006-8993(93)91681-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Trk-immunoreactivity was observed in basal forebrain and striatal cholinergic neurons, whereas low-affinity NGF receptor immunoreactivity was observed in basal forebrain but not striatal cholinergic neurons. Since NGF exerts trophic actions on both basal forebrain and striatal cholinergic populations, the presence of Trk in these neurons lends strong support for an essential role of Trk in NGF-responsive neurons, but suggests that the low affinity receptor is not necessary for NGF actions in the striatum.

引用

页码：330 / 335

页数：6

共 41 条

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