TUMOR LYSIS SYNDROME AFTER COMBINATION CHEMOTHERAPY FOR OVARIAN-CANCER

被引：35

作者：

BILGRAMI, SFA

FALLON, BG

机构：

[1] ST FRANCIS HOSP & MED CTR,DIV HEMATOL ONCOL,114 WOODLAND ST,HARTFORD,CT 06105

[2] UNIV CONNECTICUT,DIV HEMATOL ONCOL,FARMINGTON,CT 06032

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 1993年 / 21卷 / 07期

关键词：

TUMOR LYSIS SYNDROME; OVARIAN CANCER; CHEMOTHERAPY;

D O I：

10.1002/mpo.2950210712

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor lysis syndrome is infrequently encountered following the treatment of solid tumors. A 47-year-old woman developed this syndrome after receiving combination chemotherapy for ovarian cancer. The levels of serum lactate dehydrogenase, uric acid, phosphate, and creatinine increased, whereas the serum calcium level decreased. These metabolic abnormalities were treated successfully using a combination of vigorous intravenous hydration, parenteral bicarbonate to keep urinary pH > 7, furosemide, and allopurinol. This unusual and easily treatable complication should be anticipated in patients with rapidly growing ovarian cancer undergoing aggressive treatment. (C) 1993 Wiley-Liss, Inc.

引用

页码：521 / 524

页数：4

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