STRUCTURE AND SEQUENCE OF MOUSE BONE MORPHOGENETIC PROTEIN-2 GENE (BMP-2) - COMPARISON OF THE STRUCTURES AND PROMOTER REGIONS OF BMP-2 AND BMP-4 GENES

被引：64

作者：

FENG, JQ ^{[1
]}

HARRIS, MA ^{[1
]}

GHOSHCHOUDHURY, N ^{[1
]}

FENG, M ^{[1
]}

MUNDY, GR ^{[1
]}

HARRIS, SE ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT MED ENDOCRINOL,SAN ANTONIO,TX 78284

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1994年 / 1218卷 / 02期

关键词：

BONE MORPHOGENETIC PROTEIN 2; NUCLEOTIDE SEQUENCE; GENOMIC DNA; (MOUSE);

D O I：

10.1016/0167-4781(94)90017-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains similar to 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.

引用

页码：221 / 224

页数：4

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