EFFECT OF DISSOLUTION RATE OF SULFAMETHAZINE FROM TABLETS ON ABSORPTION EXCRETION OF SULFAMETHAZINE

被引：20

作者：

TARASZKA, MJ

DELOR, RA

机构：

[1] Pharmacy Research Unit, Upjohn Company, Kalamazoo, Michigan

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 02期

关键词：

Absorption rate constants—sulfamethazine; Bratton and Marshall reaction—analysis; Dissolution rate—absorption; excretion effect; Sulfamethazine—absorption;

D O I：

10.1002/jps.2600580214

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three sulfamethazine tablet formulations with in vitro drug dissolution rates of fast (T50% ∽ 1.5 min.), medium (T50% ∽ 15–20 min.), and slow (T50% ∽ 40–50 min.) were prepared to see what correlation, if any, exists between in vitro and in vivo data. A significant (at the 95% confidence interval) statistical difference existed for areas under the blood level curves and for maximum blood concentration of sulfamethazine when the fast‐dissolving formulation was compared to the slow‐dissolving formulation. The fast‐dissolving formulation gave the largest area and maximum blood concentration of sulfamethazine. The other in vivo differences between the three formulations were not significant. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：207 / &

共 8 条

[1]

Bratton AC, 1939, J BIOL CHEM, V128, P537

[2]

DELOR RA, TO BE PUBLISHED

[3]

FROST AA, 1961, KINETICS MECHANISM, P162

[4]

LEVY G, 1963, Am J Pharm Sci Support Public Health, V135, P78

[5] TABLET DISINTEGRATION AND PHYSIOLOGICAL AVAILABILITY OF DRUGS [J].