REGULATION OF GLUTATHIONE-PEROXIDASE MESSENGER-RNA LEVEL BY DIETARY SELENIUM MANIPULATION

被引:51
作者
TOYODA, H [1 ]
HIMENO, S [1 ]
IMURA, N [1 ]
机构
[1] KITASATO UNIV,SCH PHARMACEUT SCI,DEPT PUBL HLTH,5-9-1 SHIROKANE,MINATO KU,TOKYO 108,JAPAN
关键词
Glutathione peroxidase; Posttranscriptional regulation; Selenium deficiency; Transcription rate;
D O I
10.1016/0167-4781(90)90042-Z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glutathione peroxidase (GSH-Px) contains selenium at its active site as a selenocysteine moiety. We have shown that feeding mice a selenium-deficient diet for a long period caused a large decrease in the GSH-Px mRNA level as well as in GSH-Px activity both in the liver and kidneys (Toyoda, H., Himeno, S. and Imura, N. (1989) Biochim. Biophys. Acta 1008, 301-308). In the present study, the transcription rate of the GSH-Px gene was determined by a nuclear run-on assay using liver nuclei of mice fed a selenium-deficient or selenium-adequate diet. The results clearly demonstrate that the transcription rate of the GSH-Px gene was not changed by dietary selenium manipulation, indicating that dietary selenium regulates the level of GSH-Px mRNA in the post-transcriptional step. © 1990.
引用
收藏
页码:213 / 215
页数:3
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