CHALCONES - A NEW CLASS OF ANTIMITOTIC AGENTS

被引：257

作者：

EDWARDS, ML

STEMERICK, DM

SUNKARA, PS

机构：

[1] Merrell Dow Research Institute, Cincinnati, Ohio 45215

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 33卷 / 07期

关键词：

D O I：

10.1021/jm00169a021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of chalcones was evaluated as antimitotic agents. One of these, (E)l-(2,5-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl]-2-methyl-2-propen-l-one) (73), was found to be an effective antimitotic agent at a concentration of 4 nM in an in vitro HeLa cell test system. When evaluated in experimental tumor models in vivo, this compound exhibited antitumor activity against LI210 leukemia and B16 melanoma. © 1990, American Chemical Society. All rights reserved.

引用

页码：1948 / 1954

页数：7

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