ANALYSIS OF THE KINETICS OF ELECTRON-TRANSFER REACTIONS OF HEMOGLOBIN AND MYOGLOBIN WITH INORGANIC COMPLEXES

被引：29

作者：

MAUK, AG ^{[1
]}

GRAY, HB ^{[1
]}

机构：

[1] CALTECH,ARTHUR AMOS NOYES LAB CHEM PHYS,PASADENA,CA 91125

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 01期

关键词：

D O I：

10.1016/0006-291X(79)90401-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The kinetics of methemoglobin reduction by Fe(EDTA)2- have been studied and found to follow a second order rate law with k = 29.0 M-1 s-1 [25°C, μ = 0.2 M, pH 7.0 (phosphate)], ΔH‡ = 5.5 ± 0.7 kcal/mol, and ΔS†= -33 ± 2 e.u.. The electrostatics-corrected self-exchange rate constant (k11corr) for hemoglobin based on the Fe(EDTA)2- cross-reaction is 2.79×10-3 M-1 s-1. This rate constant is compared with others reported for a water-soluble iron porphyrin and calculated from published data for the reactions of myoglobin and hemoglobin with Fe(EDTA)2- and Fe(CDTA)2-/-. The k11corr values for these systems range over ten orders of magnitude with heme ≫ myoglobin > hemoglobin. © 1979.

引用

页码：206 / 210

页数：5

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