ENANTIOSELECTIVE SYNTHESIS OF A VERSATILE 2-ISOCEPHEM SYNTHON

被引：46

作者：

ASZODI, J ^{[1
]}

BONNET, A ^{[1
]}

TEUTSCH, G ^{[1
]}

机构：

[1] ROUSSEL UCLAF,CTR RECH,F-93230 ROMAINVILLE,FRANCE

来源：

TETRAHEDRON | 1990年 / 46卷 / 05期

关键词：

D O I：

10.1016/S0040-4020(01)81967-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective synthesis of the isocephem synthon 2 has been carried out by assembling 3 building blocks. Cycloaddition of phthalimido acetyl chloride with a chiral imine gave the β-lactam nucleus in 80% diastereoisomeric excess (d.e.). The elaboration of the thiazine ring was carried out using a highly functionalised epoxy ester 12 and P2I4 mediated water elimination. © 1990.

引用

页码：1579 / 1586

页数：8

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