INHIBITION OF THE DEGRADATION OF RECEPTOR-BOUND HUMAN CHORIO-GONADOTROPIN BY LEUPEPTIN

被引：19

作者：

ASCOLI, M ^{[1
]}

机构：

[1] VANDERBILT UNIV, SCH MED, DEPT BIOCHEM, NASHVILLE, TN 37232 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 586卷 / 03期

基金：

美国国家卫生研究院;

关键词：

(Leydig cell); Choriogonadotropin; Hormone degradation; Leupeptin; Lysosome; Steroidogenesis;

D O I：

10.1016/0304-4165(79)90051-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of leupeptin to block the degradation of receptor-bound human choriogonadotropin has been studied. It was found that this compound inhibited hormone degradation and intracellular cathepsin B activity in a parallel fashion, without affecting hormone-stimulated steroidogenesis. © 1979.

引用

页码：608 / 614

页数：7

共 17 条

[1] BIOLOGICAL ACTIVITIES OF LEUPEPTINS
AOYAGI, T
MIYATA, S
NANBO, M
KOJIMA, F
MATSUZAKI, M
ISHIZUKA, M
TAKEUCHI, T
UMEZAWA, H
[J]. JOURNAL OF ANTIBIOTICS, 1969, 22 (11) : 558 - +
[2] ASCOLI M, 1978, J BIOL CHEM, V253, P4892
[3] GONADOTROPIN BINDING AND STIMULATION OF STEROIDOGENESIS IN LEYDIG TUMOR-CELLS
ASCOLI, M
PUETT, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (01) : 99 - 102
[4] ASCOLI M, 1978, J BIOL CHEM, V253, P7832
[5] ASCOLI M, 1978, J BIOL CHEM, V253, P7839
[6] NEW ASSAY FOR CATHEPSIN B1 AND OTHER THIOL PROTEINASES
BARRETT, AJ
[J]. ANALYTICAL BIOCHEMISTRY, 1972, 47 (01) : 280 - &
[7] HUMAN CATHEPSIN-B1 - PURIFICATION AND SOME PROPERTIES OF ENZYME
BARRETT, AJ
[J]. BIOCHEMICAL JOURNAL, 1973, 131 (04) : 809 - +
[8] Barrett AJ, 1977, LYSOSOMES LABORATORY, P19
[9] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[10] I125 LABELED HUMAN EPIDERMAL GROWTH-FACTOR - BINDING, INTERNALIZATION, AND DEGRADATION IN HUMAN FIBROBLASTS
CARPENTER, G
COHEN, S
[J]. JOURNAL OF CELL BIOLOGY, 1976, 71 (01) : 159 - 171

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