IMPROVEMENT OF HYPERGLYCEMIA AND HYPERLIPEMIA IN STREPTOZOTOCIN-DIABETIC RATS BY A METHANOLIC EXTRACT OF PRUNUS-DAVIDIANA STEMS AND ITS MAIN COMPONENT, PRUNIN

被引：125

作者：

CHOI, JS ^{[1
]}

YOKOZAWA, T ^{[1
]}

OURA, H ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,WAKAN YAKU RES INST,DEPT APPL BIOCHEM,SUGITANI,TOYAMA 93001,JAPAN

来源：

PLANTA MEDICA | 1991年 / 57卷 / 03期

关键词：

PRUNUS-DAVIDIANA; ROSACEAE; HYPOGLYCEMIC EFFECT; HYPOLIPEMIC EFFECT; PRUNIN; STREPTOZOTOCIN-INDUCED DIABETIC RATS;

D O I：

10.1055/s-2006-960075

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Blood glucose and total lipid levels in rats with streptozotocin-induced diabetes were determined after intraperitoneal administration of a methanolic extract of Prunus davidiana Fr. stems and its main component, prunin (= naringenin 7-O-beta-D-glucoside). From the data obtained it was concluded that intraperitoneal administration of the methanolic extract and prunin produced a significant hypoglycemic effect. Total blood lipids were also decreased by these substances. Thus, it is suggested that this methanolic extract contains one or more hypoglycemic principles including the main flavanone glycoside, prunin, which can significantly reduce the levels of blood glucose and total lipids in streptozotocin-diabetic rats.

引用

页码：208 / 211

页数：4

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