SIMULTANEOUS-OPTIMIZATION OF SEVERAL CHROMATOGRAPHIC PERFORMANCE GOALS USING DERRINGER DESIRABILITY FUNCTION

被引：93

作者：

BOURGUIGNON, B ^{[1
]}

MASSART, DL ^{[1
]}

机构：

[1] VRIJE UNIV BRUSSELS,INST FARMACEUT,LAARBEEKLAAN 103,B-1090 BRUSSELS,BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 586卷 / 01期

关键词：

D O I：

10.1016/0021-9673(91)80019-D

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The desirability function, a multi-criterion decision-making method proposed by Derringer, was investigated to optimize different chromatographic performance goals. This function is a measure of overall quality and provides a convenient means to compare several chromatograms obtained by high-performance liquid chromatography (HPLC) and to select the separation with the most desirable properties. Other solutions to the problem of multi-criteria optimization in HPLC, such as the Pareto-optimality, chromatographic response functions and combined threshold criteria are compared with the proposed method, and the advantages and disadvantages of each are discussed.

引用

页码：11 / 20

页数：10

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