QUANTITATIVE-DETERMINATION OF CYCLOBENZAPRINE IN HUMAN PLASMA BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY

被引：15

作者：

HWANG, PTR ^{[1
]}

YOUNG, DA ^{[1
]}

STRAUGHN, AB ^{[1
]}

MEYER, MC ^{[1
]}

机构：

[1] UNIV TENNESSEE CTR HLTH SCI,COLL PHARM,MEMPHIS,TN 38163

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1993年 / 16卷 / 05期

关键词：

D O I：

10.1080/10826079308019578

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method is presented for the analysis of cyclobenzaprine in human plasma utilizing high pressure liquid chromatography (HPLC) with UV detection at 230 nm. Plasma, adjusted to pH 10.5, was extracted with methylene chloride:pentane 30:70 (v/v). Nortriptyline was employed as the internal standard, and chromatographic separation was achieved with a normal-phase column. Standard curves were linear over the concentration range 1.0 ng/ml to 49.0 ng/ml. The method was utilized to assay plasma samples from 24 humans given a 20 mg oral dose of cyclobenzaprine.

引用

页码：1163 / 1171

页数：9

共 5 条

[1] Cotton M. L., 1988, ANAL PROFILES DRUG S, V17, P41
[2] DISTINGUISHING CYCLOBENZAPRINE FROM AMITRIPTYLINE AND IMIPRAMINE BY LIQUID-CHROMATOGRAPHY WITH UV MULTIWAVELENGTH OR FULL-SPECTRUM DETECTION - BLOOD-LEVELS OF CYCLOBENZAPRINE IN EMERGENCY SCREENS
DEMOREST, DM
[J]. JOURNAL OF ANALYTICAL TOXICOLOGY, 1987, 11 (03) : 133 - 134
[3] EDELBROEK PM, 1982, CLIN CHEM, V28, P2143
[4] DETERMINATION OF CYCLOBENZAPRINE IN TABLETS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
HEINITZ, ML
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (06) : 656 - 658
[5] WONG SHY, 1988, CLIN CHEM, V34, P848

← 1 →