RELATIVE SPARING OF NITRIC-OXIDE SYNTHASE CONTAINING NEURONS IN THE HIPPOCAMPAL-FORMATION IN ALZHEIMERS-DISEASE

被引：165

作者：

HYMAN, BT

MARZLOFF, K

WENNIGER, JJ

DAWSON, TM

BREDT, DS

SNYDER, SH

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115

[2] JOHNS HOPKINS UNIV,DEPT NEUROSCI,BALTIMORE,MD 21218

[3] JOHNS HOPKINS UNIV,DEPT NEUROL,BALTIMORE,MD 21218

[4] JOHNS HOPKINS UNIV,DEPT PHARMACOL,BALTIMORE,MD 21218

[5] JOHNS HOPKINS UNIV,DEPT MOLEC SCI,BALTIMORE,MD 21218

[6] JOHNS HOPKINS UNIV,DEPT PSYCHIAT,BALTIMORE,MD 21218

来源：

ANNALS OF NEUROLOGY | 1992年 / 32卷 / 06期

关键词：

D O I：

10.1002/ana.410320618

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Nitric oxide (NO) is an endogenous neuromodulator that may mediate neurotoxic effects of glutamate. NO- synthesizing neurons are, however, resistant to NO- and glutamate-induced neurotoxicity. We now show that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.

引用

页码：818 / 820

页数：3

共 26 条

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