EFFECTS OF ALPHA-TOCOPHEROL AND TOCOTRIENOLS ON BLOOD-PRESSURE AND LINOLEIC-ACID METABOLISM IN THE SPONTANEOUSLY HYPERTENSIVE RAT (SHR)

被引:29
作者
KOBA, K [1 ]
ABE, K [1 ]
IKEDA, I [1 ]
SUGANO, M [1 ]
机构
[1] KYUSHU UNIV, SCH AGR 46-09, FOOD SCI LAB, FUKUOKA 812, JAPAN
关键词
D O I
10.1271/bbb.56.1420
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Both alpha-tocopherol and a 1:1.7 mixture of alpha-tocopherol and tocotrienols at a 0.2% dietary level significantly depressed the age-related increase in the systolic blood pressure of spontaneously hypertensive rats (SHRs) after 3 weeks of feeding. The aortic production of prostacyclin was increased 1.5 times both by alpha-tocopherol and a tocotrienol mixture, suggesting a possible relevance to their hypotensive effect. These vitamins did not influence the DELTA6- and DELTA5-desaturase activities of liver microsomes, but fatty acid profiles of the liver phospholipids predicted a reduction of linoleic acid desaturation. These effects were in general more clear with tocotrienols than with alpha-tocopherol. Platelet aggregation by 5 mum ADP remained uninfluenced. Thus, tocotrienols may have effects on various lipid parameters somewhat different from those of alpha-tocopherol.
引用
收藏
页码:1420 / 1423
页数:4
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