EFFECTS OF ISOSORBIDE-5-MONONITRATE AND ISOSORBIDE-2-MONONITRATE ON THE CONTRACTILE AND ELECTRICAL-ACTIVITY AND ON THE CONTENT OF CYCLIC-NUCLEOTIDES IN ISOLATED HEART MUSCLES OF THE GUINEA-PIG AND DOG

被引：3

作者：

ATANASSOVA, R

SPASSOV, G

BALANSKY, R

BOEV, K

机构：

[1] BULGARIAN ACAD SCI,INST PHYSIOL,BU-1113 SOFIA,BULGARIA

[2] NATL CTR ONCOL,BU-1156 SOFIA,BULGARIA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 08期

关键词：

D O I：

10.1111/j.2042-7158.1992.tb05490.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Isorbide-5-mononitrate and isosorbide-2-mononitrate, the metabolites of isosorbide dinitrate, were studied for their effects on the contractile and electrical activity and on the content of cyclic nucleotides in isolated heart muscles of guinea-pig and dog. Isosorbide-5-mononitrate at all concentrations tested and isosorbide-2-mononitrate at low concentrations did not produce significant changes in the mechanical activity of guinea-pig heart preparations. Isosorbide-2-mononitrate in concentrations above 10(-4) M inhibited the contractility and shortened the action potential of guinea-pig and dog heart muscle. Neither mononitrate had an effect on cAMP concentration but both induced a significant elevation of cGMP content in guinea-pig heart tissue, the effect of isosorbide-2-mononitrate being greater.

引用

页码：663 / 666

页数：4

共 19 条

[1] ATTENUATION BY ISOSORBIDE DINITRATE OF CORONARY OCCLUSION-INDUCED ACIDOSIS IN THE DOG MYOCARDIUM [J].