ASSEMBLING OF THE MOLECULAR SKELETONS USING THE CHIRAL ALLENES AS THE VERSATILE BUILDING-BLOCKS (SYNTHONS)

Allenes comprize that class of compounds characterized by a 1,2-diene grouping with an unique geometrical feature owing to the cumulated diene system. Within the last ten years, allene chemistry has considerable progressed to development of modern synthetic methodologies for a variety of desirable intermediate and natural products. On the other hand, allenes also enjoy a wide variety of reactivities in many types of reactions via ionic, radical or concerted mechanism. Here we describe the review of recent studies on syntheses of chiral allenes and cyclic compounds including heterocyclic compounds as lactones, furans, indoles, pyrrolidines, thiophenes, sulfolenes, macrolides, oxazolidinones using allenes as versatile building blocks (synthons).