BIOLOGICALLY-ACTIVE ACETOGENINS FROM STEM BARK OF ASIMINA-TRILOBA

被引：50

作者：

ZHAO, GX

RIESER, MJ

HUI, YH

MIESBAUER, LR

SMITH, DL

MCLAUGHLIN, JL

机构：

[1] Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette

来源：

PHYTOCHEMISTRY | 1993年 / 33卷 / 05期

关键词：

ASIMINA-TRILOBA; ANNONACEAE; STEM BARK; ACETOGENINS; CIS-ANNONACIN-A-ONE AND TRANS-ANNONACIN-A-ONE; CIS-CIGANTETROCINONE AND TRASN-GIGANTETROCINONE; CIS-ISOANNONACIN AND TRANS-ISOANNONACIN; SQUAMOLONE;

D O I：

10.1016/0031-9422(93)85024-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In continuing our research with cytotoxic and pesticidal components from the stem bark of the North American paw paw, Asimina triloba, the novel cytotoxic monotetrahydrofuran Annonaceous acetogenins, cis- and trans-annonacin-A-one, cis- and trans-gigantetrocinone and cis-isoannonacin, in addition to the known compounds, trans-isoannonacin and squamolone, have been identified. Brine shrimp lethality testing was used to direct the fractionation. The structures were elucidated by spectral analysis and/or chemical synthesis. These acetogenins have potent cytotoxicities against the human tumour cell lines of A-549 (lung carcinoma), MCF-7 (breast carcinoma) and HT-29 (colon adenocarcinoma).

引用

页码：1065 / 1073

页数：9

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