EXPRESSION OF PARATHYROID HORMONE-RELATED PEPTIDE GENE IN THE RAT HYPOTHALAMUS

被引：7

作者：

FRASER, RA

ZAJAC, JD

HARVEY, S

机构：

[1] UNIV ALBERTA,DEPT PHYSIOL,EDMONTON T6G 2E1,ALBERTA,CANADA

[2] MASSACHUSETTS GEN HOSP,ENDOCRINE UNIT,BOSTON,MA 02114

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1993年 / 106卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0305-0491(93)90143-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Parathyroid hormone-related peptide (PTHrP), originally isolated from human malignant tumors, is present in a variety of normal mammalian tissues, including the brain. 2. The expression and translation of the PTHrP gene within the rat hypothalamus was demonstrated in this study by the specific hybridization of a 1.8 kb mRNA product with a PTHrP cDNA probe and by the crossreactivity of rat hypothalamic extracts in a PTHrP radioimmunoassay. 3. These results suggest roles for PTHrP in neural or hypophysiotropic regulation.

引用

页码：647 / 650

页数：4

共 27 条

[1] NMR-STUDY OF A 34-RESIDUE N-TERMINAL FRAGMENT OF THE PARATHYROID-HORMONE-RELATED PROTEIN SECRETED DURING HUMORAL HYPERCALCEMIA OF MALIGNANCY [J].