RAPID DEVELOPMENT OF TOLERANCE TO MORPHINE IN THE FORMALIN TEST

被引：15

作者：

CONNELL, BJ ^{[1
]}

BARNES, JC ^{[1
]}

BLATT, T ^{[1
]}

TASKER, RAR ^{[1
]}

机构：

[1] UNIV PRINCE EDWARD ISL, ATLANTIC VET COLL, DEPT ANAT & PHYSIOL, CHARLOTTETOWN C1A 4P3, PE, CANADA

来源：

NEUROREPORT | 1994年 / 5卷 / 07期

关键词：

OPIOID TOLERANCE; PAIN; ANALGESIA; FORMALIN TEST; MORPHINE;

D O I：

10.1097/00001756-199403000-00020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

PREVIOUS reports have suggested that tolerance to the antinociceptive effects of morphine does not develop in the formalin test. To re-examine these findings, morphine was administered via multiple injections or continuous infusion from 0 to 4 days prior to testing with either the formalin or tail-flick test. Following twice daily injections (5.0 mg kg(-1) s.c.), significant tolerance developed within 2 days with the formalin test but not until day 4 with the tail-flick test. Significant tolerance was noted with both tests 4 days following the implantation of osmotic minipumps (10 mg kg(-1) day(-1), s.c.). We conclude that in mice, tolerance to the analgesic effects of morphine develops rapidly with the formalin test.

引用

页码：817 / 820

页数：4

共 25 条

[1] APPARENT LACK OF TOLERANCE IN THE FORMALIN TEST SUGGESTS DIFFERENT MECHANISMS FOR MORPHINE ANALGESIA IN DIFFERENT TYPES OF PAIN [J].