REPLICATION OF MOLLUSCUM CONTAGIOSUM VIRUS

被引：40

作者：

BULLER, RML

BURNETT, J

CHEN, W

KREIDER, J

机构：

[1] NIAID,VIRAL DIS LAB,BETHESDA,MD 20892

[2] UNIV MARYLAND,DEPT DERMATOL,BALTIMORE,MD 21201

[3] PENN STATE UNIV,COLL MED,DEPT EXPTL PATHOL,HERSHEY,PA 17033

来源：

VIROLOGY | 1995年 / 213卷 / 02期

关键词：

D O I：

10.1006/viro.1995.0037

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Molluscum contagiosum virus (MCV) infects preadolescent children and sexually active adults, frequently causing a disfiguring cutaneous disease in immunosuppressed HIV-infected individuals. The development of an efficacious treatment regime has been hampered by the failure to replicate the virus in the laboratory. Here we report the first demonstration of MCV replication in an experimental system. In human foreskin grafts to athymic mice, MCV induced morphological changes which were indistinguishable from patient biopsies and included the development and migration of molluscum bodies containing mature virions to the epidermal surface. (C) 1995 Academic Press, Inc.

引用

页码：655 / 659

页数：5

共 31 条

[1] HUMAN-EPIDERMIS RECONSTRUCTED BY CULTURE - IS IT NORMAL [J].