INVESTIGATION OF THE ANTIINFLAMMATORY EFFECTS OF PAEDERIA-FOETIDA

被引：50

作者：

DE, S

RAVISHANKAR, B

BHAVSAR, GC

机构：

[1] Institute of Post Graduate Teaching and Research, Gujarat Ayurved University, Jamnagar, 361 008 Gujarat, Dhanvantari Mandir

[2] 15, Sadhana Colony

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1994年 / 43卷 / 01期

关键词：

PAEDERIA FOETIDA; RUBIACEAE; ANTIINFLAMMATORY; COTTON-PELLET GRANULOMA; DISEASE-MODIFYING ANTIRHEUMATIC ACTIVITY;

D O I：

10.1016/0378-8741(94)90113-9

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A detailed investigation on the anti-inflammatory activity of the butanol fraction of a methanol extract (BMEL) of the defatted leaves of Paederia foetida was undertaken to find the pharmacological basis for the ethnomedical use of the plant. This fraction produced a significant inhibition of granulation tissue formation in cotton-pellet implanted rats. It decreased liver aspartate transaminase activity without affecting serum aspartate transaminase activity. It did not, however, affect adrenal weight and ascorbic acid content significantly, thus ruling out a stimulation of the adrenal-pituitary axis. BMEL antagonised hyposaline-induced haemolysis of human red blood cells and an elevation of rat serum acid phosphatase activity, indicating the presence of a membrane stabilising activity. It also inhibited the elevation of serum orosomucoid levels in rats, suggesting the possibility of the presence of disease-modifying antirheumatic activity. The results indicate that there is some rationale behind the ethnomedical use of the plant for treating inflammatory disorders.

引用

页码：31 / 38

页数：8

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