EFFICIENT COUPLING OF AMINO-ACID DERIVATIVES TO RIGID ORGANIC SCAFFOLDS - MODEL SYNTHESES FOR DE-NOVO PROTEINS

被引：42

作者：

GIBB, BC ^{[1
]}

MEZO, AR ^{[1
]}

CAUSTON, AS ^{[1
]}

FRASER, JR ^{[1
]}

TSAI, FCS ^{[1
]}

SHERMAN, JC ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT CHEM,VANCOUVER,BC V6T 1Z1,CANADA

来源：

TETRAHEDRON | 1995年 / 51卷 / 32期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/0040-4020(95)00485-Q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the coupling of amino acid derivatives to four different rigid organic macrocycles. The couplings were achieved in high yields, which augurs well for the coupling of polypeptides to the rigid macrocycles to create a new family of de novo proteins. We discuss the structure of the model compounds based on the hydrogen bonding patterns that are evident from their NMR and IR spectra.

引用

页码：8719 / 8732

页数：14

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