AN INTEGRAL MEMBRANE COMPONENT OF COATOMER-COATED TRANSPORT VESICLES DEFINES A FAMILY OF PROTEINS INVOLVED IN BUDDING

被引：197

作者：

STAMNES, MA ^{[1
]}

CRAIGHEAD, MW ^{[1
]}

HOE, MH ^{[1
]}

LAMPEN, N ^{[1
]}

GEROMANOS, S ^{[1
]}

TEMPST, P ^{[1
]}

ROTHMAN, JE ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR, PROGRAM MOLEC BIOL, NEW YORK, NY 10021 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 17期

关键词：

D O I：

10.1073/pnas.92.17.8011

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have isolated a major integral membrane protein from Golgi derived coatomer-coated vesicles, This 24-kDa protein, p24, defines a family of integral membrane proteins with homologs present in yeast and humans, In addition to sequence similarity, all p24 family members contain a motif with the characteristic heptad repeats found in coiled coils, When the yeast p24 isoform, yp24A, is knocked out in a strain defective for vesicle fusion, a dramatic reduction in the accumulation of transport vesicles is observed, Together, these results indicate a role for this protein family in the budding of coatamer-coated and other species of coated vesicles.

引用

页码：8011 / 8015

页数：5

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