Role of micro RNAs in cardiac hypertrophy, myocardial fibrosis and heart failure

被引：36

作者：

Dong, De-li ^{[1
]}

Yang, Bao-feng ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Pharmacol, Biopharmaceut Key Lab Heilongjiang Prov, Harbin 150086, Heilongjiang, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2011年 / 1卷 / 01期

关键词：

microRNAs; Cardiac hypertrophy; Myocardial fibrosis; Heart failure;

D O I：

10.1016/j.apsb.2011.04.010

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules that post transcriptionally regulate gene expression. MiRNA expression and function in heart disease remain to be determined but modulation of miRNA expression in vivo has revealed that miRNAs play an important role in controlling heart function and structure. In fact, abnormal expression of miRNAs may initiate and contribute to the progress of heart disease. Here, we summarize the literature relating to the involvement of miRNAs in cardiac hypertrophy, myocardial fibrosis and heart failure. (C) 2011 Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：1 / 7

页数：7

共 73 条

[1]

Plasma MicroRNA 499 as a Biomarker of Acute Myocardial Infarction [J].

Adachi, Taichi ;

Nakanishi, Michio ;

Otsuka, Yoritaka ;

Nishimura, Kunihiro ;

Hirokawa, Gou ;

Goto, Yoichi ;

Nonogi, Hiroshi ;

Iwai, Naoharu .

CLINICAL CHEMISTRY, 2010, 56 (07) :1183-1185

[2]

Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction [J].

Ai, Jing ;

Zhang, Rong ;

Li, Yue ;

Pu, Jielin ;

Lu, Yanjie ;

Jiao, Jundong ;

Li, Kang ;

Yu, Bo ;

Li, Zhuqin ;

Wang, Rongrong ;

Wang, Lihong ;

Li, Qiang ;

Wang, Nina ;

Shan, Hongli ;

Li, Zhongyu ;

Yang, Baofeng .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 391 (01) :73-77

[3]

microRNAs: Tiny regulators with great potential [J].

Ambros, V .

CELL, 2001, 107 (07) :823-826

[4]

MicroRNAs Regulating a Change of Heart [J].

Barringhaus, Kurt G. ;

Zamore, Phillip D. .

CIRCULATION, 2009, 119 (16) :2217-2224

[5]

Cai Ben-zhi, 2009, Yaoxue Xuebao, V44, P833

[6]

MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice [J].

Callis, Thomas E. ;

Pandya, Kumar ;

Seok, Hee Young ;

Tang, Ru-Hang ;

Tatsuguchi, Mariko ;

Huang, Zhan-Peng ;

Chen, Jian-Fu ;

Deng, Zhongliang ;

Gunn, Bronwyn ;

Shumate, Janelle ;

Willis, Monte S. ;

Selzman, Craig H. ;

Wang, Da-Zhi .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (09) :2772-2786

[7]

MicroRNA-133 controls cardiac hypertrophy [J].

Care, Alessandra ;

Catalucci, Daniele ;

Felicetti, Federica ;

Bonci, Desiree ;

Addario, Antonio ;

Gallo, Paolo ;

Bang, Marie-Louise ;

Segnalini, Patrizia ;

Gu, Yusu ;

Dalton, Nancy D. ;

Elia, Leonardo ;

Latronico, Michael V. G. ;

Hoydal, Morten ;

Autore, Camillo ;

Russo, Matteo A. ;

Dorn, Gerald W., II ;

Ellingsen, Oyvind ;

Ruiz-Lozano, Pilar ;

Peterson, Kirk L. ;

Croce, Carlo M. ;

Peschle, Cesare ;

Condorelli, Gianluigi .

NATURE MEDICINE, 2007, 13 (05) :613-618

[8]

The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation [J].

Chen, JF ;

Mandel, EM ;

Thomson, JM ;

Wu, QL ;

Callis, TE ;

Hammond, SM ;

Conlon, FL ;

Wang, DZ .

NATURE GENETICS, 2006, 38 (02) :228-233

[9]

Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure [J].

Chen, Jian-Fu ;

Murchison, Elizabeth P. ;

Tang, Ruhang ;

Callis, Thomas E. ;

Tatsuguchi, Mariko ;

Deng, Zhongliang ;

Rojas, Mauricio ;

Hammond, Scott M. ;

Schneider, Michael D. ;

Selzman, Craig H. ;

Meissner, Gerhard ;

Patterson, Cam ;

Hannon, Gregory J. ;

Wang, Da-Zhi .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (06) :2111-2116

[10]

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing [J].

Chendrimada, TP ;

Gregory, RI ;

Kumaraswamy, E ;

Norman, J ;

Cooch, N ;

Nishikura, K ;

Shiekhattar, R .

NATURE, 2005, 436 (7051) :740-744

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