INTERACTION BETWEEN DELTA-9-TETRAHYDROCANNABINOL AND MORPHINE ON THE MOTOR-ACTIVITY OF MICE

被引:12
作者
AYHAN, IH
KAYMAKCALAN, S
TULUNAY, FC
机构
[1] Department of Pharmacology, Ankara University Medical School, Ankara, Sihhiye
关键词
Δ[!sup]9[!/sup]-Tetrahydrocannabinol; Morphine; Motor activity; Synergism;
D O I
10.1007/BF00429697
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The present experiments dealt the effects of Δ9-tetrahydrocannabinol (THC) on the locomotor activity stimulating action of morphine in mice. In the first series of experiments, the pretreatments of mice by THC in doses up to 20 mg/kg have been found to potentiate the morphine-induced hyperactivity in dose-dependent manner, but higher doses of THC did not produce such an action. In the second series of experiments the dose-response curve of morphine for the motor activity has been found to shift to the left by the pretreatment of mice with 10 mg/kg of THC. These results show a synergism between morphine and THC and suggest that both drugs may share some common site of action. © 1979 Springer-Verlag.
引用
收藏
页码:169 / 172
页数:4
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