PREVENTION OF MURINE CEREBRAL MALARIA BY A STABLE PROSTACYCLIN ANALOG

被引：11

作者：

SLIWA, K

GRUNDMANN, HJ

NEIFER, S

CHAVES, MF

SAHLMULLER, G

BLITSTEINWILLINGER, E

BIENZLE, U

KREMSNER, PG

机构：

[1] LANDESINST TROPENMED BERLIN, W-1000 BERLIN 19, GERMANY

[2] SCHERING AG BERLIN, BERLIN, GERMANY

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 10期

关键词：

D O I：

10.1128/IAI.59.10.3846-3848.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Iloprost, a synthetic prostacyclin analog, successfully prevents the development of cerebral malaria in mice. Malaria antigen-induced tumor necrosis factor (TNF) production could be inhibited by iloprost in vitro and in vivo. Northern analysis of TNF mRNA revealed that malaria antigen-induced TNF expression was suppressed at the transcription level.

引用

页码：3846 / 3848

页数：3

共 16 条

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