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POLYALKYLCYANOACRYLATE NANOPARTICLES AS DRUG CARRIER - PRESENT STATE AND PERSPECTIVES

被引：108
作者：
COUVREUR, P
VAUTHIER, C
机构：
[1] University of Paris XI. Laboratoire de Pharmacie Galénique et Biopharmacie, Châtenay-Malabry
来源：
JOURNAL OF CONTROLLED RELEASE | 1991年 / 17卷 / 02期
关键词：
POLYALKYL CYANOACRYLATE NANOPARTICLES; DRUG TARGETING; CANCER CHEMOTHERAPY; INTRACELLULAR ANTIBIOTHERAPY; BIODEGRADATION; RES UPTAKE;
D O I：
10.1016/0168-3659(91)90058-L
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The use of biodegradable nanoparticles as carrier for delivering drugs is considered with particular reference to the application in cancer chemotherapy and intracellular antibiotherapy. Physico-chemical properties and characterization of these particles, as well as drug payload, are discussed. Special attention is given to the mechanism of bioerosion of nanoparticles both in vitro and in vivo. Information is also given concerning the interaction with cells in culture.
引用
收藏
页码：187 / 198
页数：12
相关论文
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