REVERSIBLE THYROID-DYSFUNCTION DURING TREATMENT WITH GM-CSF

被引：52

作者：

HOEKMAN, K

VONBLOMBERGVANDERFLIER, BME

WAGSTAFF, J

DREXHAGE, HA

PINEDO, HM

机构：

[1] FREE UNIV AMSTERDAM HOSP,DEPT MED ONCOL,DE BOELELAAN 1117,1007 MB AMSTERDAM,NETHERLANDS

[2] FREE UNIV AMSTERDAM HOSP,DEPT PATHOL,AMSTERDAM,NETHERLANDS

[3] ERASMUS UNIV,DEPT IMMUNOL,3000 DR ROTTERDAM,NETHERLANDS

来源：

LANCET | 1991年 / 338卷 / 8766期

关键词：

D O I：

10.1016/0140-6736(91)91103-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250-mu-g/m2 intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.

引用

收藏

页码：541 / 542

页数：2

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