CELL CELL CONTACT MODULATES EXPRESSION OF CELL-ADHESION MOLECULE-L1 IN PC12-CELLS

被引：15

作者：

KOBAYASHI, H

MIZUKI, T

WADA, A

IZUMI, F

机构：

[1] Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Yahatanishi-ku, Kitakyushu

来源：

NEUROSCIENCE | 1992年 / 49卷 / 02期

关键词：

D O I：

10.1016/0306-4522(92)90108-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of cell contact on the expression of cell adhesion molecule Ll was investigated. The rat pheochromocytoma cell line PC12 cells were cultured at various densities in the presence or absence of the nerve growth factor. The addition of the nerve growth factor promoted the expression of L1. The expression of L1 was higher when the cells were cultured at high density than when done at low density both in the presence or absence of the nerve growth factor. Immunohistochemical staining of L1 showed that the expression of L1 was higher in the cells contacting each other. These results show that cell interaction affects the expression of cell adhesion molecule Ll in the PC12 cells.

引用

页码：437 / 441

页数：5

共 16 条

[1] ADHESION MOLECULES AND ANIMAL DEVELOPMENT [J].

ANDERSON, H .

EXPERIENTIA, 1990, 46 (01) :2-13

[2] DEMONSTRATION OF IMMUNOCHEMICAL IDENTITY BETWEEN THE NERVE GROWTH FACTOR-INDUCIBLE LARGE EXTERNAL (NILE) GLYCOPROTEIN AND THE CELL ADHESION-L1 [J].

BOCK, E ;

RICHTERLANDSBERG, C ;

FAISSNER, A ;

SCHACHNER, M .

EMBO JOURNAL, 1985, 4 (11) :2765-2768

[3]

DOHERTY P, 1987, DEVELOPMENT, V101, P605

[4] CELL-ADHESION MOLECULES [J].

EDELMAN, GM .

SCIENCE, 1983, 219 (4584) :450-457

[5] BIOSYNTHESIS AND MEMBRANE TOPOGRAPHY OF THE NEURAL CELL-ADHESION MOLECULE L1 [J].

FAISSNER, A ;

TEPLOW, DB ;

KUBLER, D ;

KEILHAUER, G ;

KINZEL, V ;

SCHACHNER, M .

EMBO JOURNAL, 1985, 4 (12) :3105-3113

[6] THE NEURAL CELL-ADHESION MOLECULE L1 IS DISTINCT FROM THE N-CAM RELATED GROUP OF SURFACE-ANTIGEN BSP-2 AND ANTIGEN-D2 [J].

FAISSNER, A ;

KRUSE, J ;

GORIDIS, C ;

BOCK, E ;

SCHACHNER, M .

EMBO JOURNAL, 1984, 3 (04) :733-737

[7] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].

LAEMMLI, UK .

NATURE, 1970, 227 (5259) :680-+

[8]

LUCASS CA, 1979, EXP CELL RES, V12, P79

[9] NGF STIMULATES INCORPORATION OF FUCOSE OR GLUCOSAMINE INTO AN EXTERNAL GLYCOPROTEIN IN CULTURED RAT PC12 PHEOCHROMOCYTOMA CELLS [J].

MCGUIRE, JC ;

GREENE, LA ;

FURANO, AV .

CELL, 1978, 15 (02) :357-365

[10] NEURAL ADHESION MOLECULE L1 AS A MEMBER OF THE IMMUNOGLOBULIN SUPERFAMILY WITH BINDING DOMAINS SIMILAR TO FIBRONECTIN [J].

MOOS, M ;

TACKE, R ;

SCHERER, H ;

TEPLOW, D ;

FRUH, K ;

SCHACHNER, M .

NATURE, 1988, 334 (6184) :701-703

← 1 2 →