A DOSE-RESPONSE STUDY OF INTRAVENOUS META-CHLOROPHENYLPIPERAZINE IN NORMAL SUBJECTS

被引：23

作者：

KALUS, O ^{[1
]}

WETZLER, S ^{[1
]}

KAHN, RS ^{[1
]}

ASNIS, GM ^{[1
]}

VANPRAAG, HM ^{[1
]}

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,MONTEFIORE MED CTR,DEPT PSYCHIAT,BRONX,NY 10461

来源：

PSYCHOPHARMACOLOGY | 1992年 / 106卷 / 03期

关键词：

MCPP; SEROTONIN; DOSE-RESPONSE; INTRAVENOUS;

D O I：

10.1007/BF02245423

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A placebo-controlled dose-response study of the direct serotonin receptor agonist m-chlorophenylpiperazine (MCPP), intravenously infused over 90 s in 0.06 and 0.08 mg/kg doses, was conducted in nine normal male subjects. Cortisol, prolactin, MCPP serum levels and behavioral responses were measured over a 210-min period. Both doses caused significant cortisol and prolactin release and were associated with significantly greater behavioral effects as compared to placebo. Though the two doses were associated with different MCPP serum levels, they did not significantly differ in their hormonal and behavioral effects.

引用

页码：388 / 390

页数：3

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