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CHOLINERGIC AGONISTS AND INTERLEUKIN-1 REGULATE PROCESSING AND SECRETION OF THE ALZHEIMER BETA/A4 AMYLOID PROTEIN-PRECURSOR

被引：519
作者：
BUXBAUM, JD
OISHI, M
CHEN, HI
PINKASKRAMARSKI, R
JAFFE, EA
GANDY, SE
GREENGARD, P
机构：
[1] TEL AVIV UNIV, DEPT BIOCHEM, IL-69978 TEL AVIV, ISRAEL
[2] CORNELL UNIV, MED CTR, DEPT MED, NEW YORK, NY 10021 USA
[3] CORNELL UNIV, MED CTR, DEPT NEUROL & NEUROSCI, NEW YORK, NY 10021 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 21期
关键词：
DEMENTIA; PROTEOLYSIS; PROTEIN KINASE; PROTEIN PHOSPHORYLATION;
D O I：
10.1073/pnas.89.21.10075
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 [理学]; 0710 [生物学]; 09 [农学];
摘要：
Activation of protein kinase C by phorbol esters is known to accelerate the processing and secretion of the beta/A4 amyloid protein precursor. We have now examined various first messengers that increase protein kinase C activity of target cells for their ability to affect beta/A4 amyloid protein precursor metabolism. Acetylcholine and interleukin 1, which are altered in Alzheimer disease, were shown to increase processing of the beta/A4 amyloid protein precursor via the secretory cleavage pathway. Cholinergic agonists stimulated secretion in human glioma and neuroblastoma cells as well as in PC12 cells transfected with the M1 receptor, while interleukin 1 stimulated secretion in human endothelial and glioma cells.
引用
收藏
页码：10075 / 10078
页数：4
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