HIGH-PERFORMANCE LIGAND-EXCHANGE LIQUID-CHROMATOGRAPHY OF FLUORO DERIVATIVES OF ALANINE

被引：4

作者：

GALUSHKO, SV

SHISHKINA, IP

GERUS, II

KOLYCHEVA, MT

机构：

[1] Institute of Bioorganic Chemistry and Oil Chemistry, Academy of Sciences of the Ukraine

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 600卷 / 01期

关键词：

D O I：

10.1016/0021-9673(92)85440-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The separation of enantiomers of 3-fluoroalanine, 3,3-difluoroalanine and 3,3,3-trifluoroalanine on ChiralProCu, ChiralValCu and Chiral-1 Nucleosil columns was studied. The substitution of hydrogen for fluorine atoms results in a significant increase in the selectivity of separation of the enantiomers. The relationship between the number of fluorine atoms and the retention of enantiomers on different columns was studied. Optimum conditions for the separation of enantiomers were found.

引用

页码：83 / 85

页数：3

共 8 条

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