MEMBERS OF A FAMILY OF DROSOPHILA PUTATIVE ODORANT-BINDING PROTEINS ARE EXPRESSED IN DIFFERENT SUBSETS OF OLFACTORY HAIRS

被引:306
作者
PIKIELNY, CW
HASAN, G
ROUYER, F
ROSBASH, M
机构
[1] BRANDEIS UNIV,DEPT BIOL,WALTHAM,MA 02254
[2] NATL CTR BIOL SCI,TIFR CTR,BANGALORE 560012,INDIA
关键词
D O I
10.1016/0896-6273(94)90150-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A polymerase chain reaction-based method was used to generate a Drosophila melanogaster antennal cDNA library from which head cDNAs were subtracted. We identified five cDNAs that code for antennal proteins containing six cysteines in a conserved pattern shared with known moth antennal proteins, including pheromone-binding proteins. Another cDNA codes for a protein related to vertebrate brain proteins that bind hydrophobic ligands. In all, we describe seven antennal proteins which contain potential signal peptides, suggesting that, like pheromone-binding proteins, they may be secreted in the lumen of olfactory hairs. The expression patterns of these putative odorant-binding proteins define at least four different subsets of olfactory hairs and suggest that the Drosophila olfactory apparatus is functionally segregated.
引用
收藏
页码:35 / 49
页数:15
相关论文
共 78 条
[1]  
Altner H., 1980, International Review of Cytology, V67, P69, DOI 10.1016/S0074-7696(08)62427-4
[2]   BASIC LOCAL ALIGNMENT SEARCH TOOL [J].
ALTSCHUL, SF ;
GISH, W ;
MILLER, W ;
MYERS, EW ;
LIPMAN, DJ .
JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) :403-410
[3]   OLFACTORY PHYSIOLOGY IN THE DROSOPHILA ANTENNA AND MAXILLARY PALP - ACJ6 DISTINGUISHES 2 CLASSES ODORANT PATHWAYS [J].
AYER, RK ;
CARLSON, J .
JOURNAL OF NEUROBIOLOGY, 1992, 23 (08) :965-982
[4]   GENETICS OF OLFACTORY BEHAVIOR IN DROSOPHILA-MELANOGASTER [J].
AYYUB, C ;
PARANJAPE, J ;
RODRIGUES, V ;
SIDDIQI, O .
JOURNAL OF NEUROGENETICS, 1990, 6 (04) :243-262
[5]   PCR-BASED CDNA LIBRARY CONSTRUCTION - GENERAL CDNA LIBRARIES AT THE LEVEL OF A FEW CELLS [J].
BELYAVSKY, A ;
VINOGRADOVA, T ;
RAJEWSKY, K .
NUCLEIC ACIDS RESEARCH, 1989, 17 (08) :2919-2932
[6]  
Breer H, 1992, Curr Opin Neurobiol, V2, P439, DOI 10.1016/0959-4388(92)90177-M
[7]   A NOVEL MULTIGENE FAMILY MAY ENCODE ODORANT RECEPTORS - A MOLECULAR-BASIS FOR ODOR RECOGNITION [J].
BUCK, L ;
AXEL, R .
CELL, 1991, 65 (01) :175-187
[8]   MOLECULAR ANALYSIS OF THE LOCUS ELAV IN DROSOPHILA-MELANOGASTER - A GENE WHOSE EMBRYONIC EXPRESSION IS NEURAL SPECIFIC [J].
CAMPOS, AR ;
ROSEN, DR ;
ROBINOW, SN ;
WHITE, K .
EMBO JOURNAL, 1987, 6 (02) :425-431
[9]   OLFACTION IN DROSOPHILA - GENETIC AND MOLECULAR ANALYSIS [J].
CARLSON, J .
TRENDS IN NEUROSCIENCES, 1991, 14 (12) :520-524
[10]   MOLECULAR-CLONING OF PUTATIVE ODORANT-BINDING AND ODORANT-METABOLIZING PROTEINS [J].
DEAR, TN ;
CAMPBELL, K ;
RABBITTS, TH .
BIOCHEMISTRY, 1991, 30 (43) :10376-10382